Two genetically closely related pigeon paramyxovirus type 1 (PPMV-1) variants with identical velogenic fusion protein cleavage sites but with strongly contrasting virulence
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چکیده
منابع مشابه
Characterization of Pigeon Paramyxovirus Type 1 Viruses (PPMV-1) Isolated from Iran
Newcastle disease (ND) is one of the contagious viral diseases in avian species. Recently, several ND outbreaks in pigeon caused by pigeon paramyxovirus serotype-1 (PPMV-1) have been reported in limited numbers from Iran and phylogenetic studies have been conducted on partial sequence of NDV fusion (F) gene. In the present study, ten PPMV-1, named Pigeon_paramyxovirus1_isolate_pigeon/Iran/UT_EG...
متن کاملCharacterization of a pigeon paramyxovirus (PPMV-1) isolated from chickens in South Africa.
A paramyxovirus with a thermostability of 60 min (typical of velogenic viruses) and a mean death time of > 90 h (typical of lentogenic viruses) was isolated from layers near Mooi River, South Africa. Our results, based on comparative nucleotide sequence data indicated that the virus is pigeon paramyxovirus 1 (PPMV-1), a variant of Newcastle disease virus. The F0 cleavage site contains a 112RRKK...
متن کاملGenetic characterization and phylogeny of pigeon paramyxovirus isolate (PPMV-1) from Pakistan
BACKGROUND Knowing the genome characteristics of circulating Newcastle disease viruses [avian paramyxoviruses (APMV-1) and pigeon paramyxoviruses (PPMV-1)] is important to devise appropriate diagnostics and control strategies. APMVs originating from chicken and wildlife in Pakistan are well-elucidated; nevertheless, molecular characterization for the circulating PPMV-1 is largely unknown. FIN...
متن کاملCharacteristics of pigeon paramyxovirus serotype-1 isolates (PPMV-1) from the Russian Federation from 2001 to 2009.
Monitoring programs for highly dangerous avian diseases in the Russian Federation from 2001 to 2009 detected 77 samples that were PCR positive for avian paramyxovirus serotype-1 (APMV-1) from sick or dead feral and domestic pigeons. Nucleotide sequences of the fusion (F) gene, including a nucleotide sequence encoding the F protein cleavage site, were determined for these isolates. All of the st...
متن کاملDifferent Regions of the Newcastle Disease Virus Fusion Protein Modulate Pathogenicity
Newcastle disease virus (NDV), also designated as Avian paramyxovirus type 1 (APMV-1), is the causative agent of a notifiable disease of poultry but it exhibits different pathogenicity dependent on the virus strain. The molecular basis for this variability is not fully understood. The efficiency of activation of the fusion protein (F) is determined by presence or absence of a polybasic amino ac...
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ژورنال
عنوان ژورنال: Veterinary Microbiology
سال: 2010
ISSN: 0378-1135
DOI: 10.1016/j.vetmic.2009.11.021